Instructors:   Prof. Simona Viglio (General Chemistry, 2 CFU)

Office location: Department of Molecular Medicine, Biochemistry Unit, Via Taramelli 3, 27100, Pavia.

Email: simona.viglio@unipv.it

Office hours: by email appointment (contact me to arrange day & time).

Prof. Livia Visai (Organic Chemistry, 2 CFU)

Office location: Department of Molecular Medicine, Biochemistry Unit, Via Taramelli 3, 27100, Pavia

Email: livia.harvey@unipv.it

Office hours: by email appointment.

Prof. Monica Galliano (Organic Chemistry, 1 CFU)

Office location: Department of Molecular Medicine, Biochemistry Unit, Via Taramelli 3, 27100, Pavia

Email: livia.visai@unipv.it

Office hours: by email appointment.

Required textbooks:

Katherine J Denniston, Joseph J Topping and Robert L Caret. General, Organic & Biochemistry. 7th Ed. 2010. McGraw-Hill Higher Education.

H. Hart, L.E. Craine, D.J. Hart, C.M. Hadad. Organic Chemistry. A Short Course. 12th edition. Houghton Mifflin Company; Boston/New York.

Prerequisites

A basic knowledge on Physics is required.

Course purpose

The aim of the Chemistry course is the acquisition of the chemical structure, the properties and the transformation of the different classes of substances (inorganic and organic) in order to understand the basic chemical properties and transformation of the molecules in living organisms.

Course topics

General Chemistry

Elements and compounds. Atoms and molecules (symbolic chemistry; molecular formulas). Periodic system of the elements and electronic configuration; element valence and oxidation state.

Intramolecular bonds: nature and polarity; molecular shape (structural formulas). Intermolecular bonds. Inorganic compounds: binary compounds of hydrogen and compounds containing oxygen. Nomenclature of inorganic compounds. Electrolytes. Acid base reactions and formation of salts.

Aggregation states of the matter: definition of the solid state and description of the different types of crystalline solids. Definition of the liquid states. Vapor pressure and surface tension. Definition of gaseous state. A brief presentation of ideal gases' laws and the kinetic molecular theory of ideal gases.

Solutions: definition, different types and qualitative and quantitative characterization. Thermodynamical considerations on solubility. Colligative properties: depression of the vapor pressure of the solvent and osmotic pressure.

Thermodynamical chemistry: how spontaneously large is the degree of conversion reactants to products? Enthalpy, enthropy and free energy. Chemical equilibrium. Kinetics: Collision theory, steric requirements, energetic factor and influence of concentration and temperature. Activated complex theory and activation energy. Catalysis.

Acid-base equilibria: Broensted and Lowry's theory on acids and bases. Self-ionization of water. Definition of pH. Calculation of pH in solutions containing strong acids, weak acids, strong bases, weak bases and salts. Buffers.

Oxidations and reductions: spontaneity and redox potential; electrochemical series; electrochemical potential; Nernst equation.

Organic chemistry

Organic Molecules in 3D. Functional groups: Nomenclature, Structure and Reactions. Aliphatic and aromatic hydrocarbons, Alkenes, Alcohols, Aldehydes/Ketones, Amines; Carboxylic Acids and Derivatives. Enol and Enolate chemistry.

Examination format

Written exam including a) practical questions on acid-base reactions, calculation of pH of salt solutions and buffers and electrochemistry; b) theoretical q